LB888 Role of MFN2 gene as prognostic biomarker for cutaneous squamous cell carcinoma recurrence

Although vast amount of research has been done on genes related to cancers, it remains unclear whether Mitofusin2 (MFN2) functions as a tumor suppressor or oncoprotein. The impact MFN2 carcinogenesis is likely be more complicated than expected, so further needed. We aimed investigate the effect pathogenesis cutaneous squamous cell carcinoma (cSCC) and analyzed expression in cSCC tissue investigated influence biological behavior cSCC. In this retrospective study, 111 patients treated with Mohs micrographic surgery (MMS) at Department Dermatology Severance hospital from 2000 2017 were reviewed. was examined by immunohistochemistry specimens, 93 primary no recurrence 18 recurrence. Correlation between various clinicopathologic factors including analyzed. Moreover, cells vitro. surgical samples, immunoreactivity against low 65 (58.6%) tissues high 46 (41.4%) tissues. Recurrence-free survival significantly size, differentiation status, MFN2, according Kaplan-Meier analysis. multivariate analysis using age, gender, lesion site, level cofactors, an independent risk factor for hazard ratio 8.262 (95% CI, 2.070-32.974; p=0.003). proliferative, migratory, invasive abilities decreased after MFN2-knockdown control (all p<0.001). conclusion, found that significant indicator poor prognosis among strong This study suggests may act oncogene affecting aggressiveness can used biomarker predict